{"title":"Brain Health","description":null,"products":[{"product_id":"adrenal-support-cordyceps-and-rhodiola","title":"Adrenal Support Cordyceps and Rhodiola","description":"\u003cp\u003e\u003cstrong\u003eCordyceps sinensis (cordyceps)\u003c\/strong\u003e \u003c\/p\u003e\u003cp\u003eAs a highly regarded cornerstone of Chinese medicine, cordyceps has been used for centuries for its far-reaching restorative effects. It is a safe, highly valued herb with activities that support nearly every physiological system impacted by the body’s response to normal everyday stressors, including the immune and cardiovascular systems. Cordyceps has been used to support good balance, strength, and a healthy body weight. It is also widely and traditionally used to increase energy and enhance stamina. It has a positive effect on blood sugar and fat metabolism, which is important because fats and sugars are actively mobilized during activation of the stress response to supply the body with extra energy. Traditional Chinese Medicine (TCM) practitioners also recommend the regular use of cordyceps to strengthen the body. Furthermore, the cell-protective and antioxidant activities of cordyceps have been documented.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRhodiola rosea (rhodiola)\u003c\/strong\u003e \u003c\/p\u003e\u003cp\u003eThis adaptogenic herb has been used traditionally in Eastern Europe and Asia for centuries to increase stamina, maintain a healthy mood, support the nervous and immune systems, and maintain healthy male sexual function. According to Panossian et al, experimental studies performed on isolated organs, tissues, cells, and enzymes demonstrate that rhodiola preparations exhibit adaptogenic effects that support nerve, brain, and heart health and are calming, longevity-enhancing, and central nervous system-stimulating. In addition, experimental animal models suggest that the root extract may be able to support normal heart rhythm. Rhodiola may also have a positive effect on brain neurotransmitters, such as dopamine and serotonin, and may influence endogenous opioid levels. According to a review of the literature on rhodiola, supplementation supports healthy work performance, quality of sleep, appetite, and energy levels subsequent to intense physical or intellectual strain. Salidrosides and rosavin have been identified as primary actives. The rhodiola extract in this formula is standardized to provide no less than 1%-3% salidrosides and 3% rosavin.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePanax ginseng (ginseng)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e As an important herbal remedy in TCM, ginseng has been used for thousands of years, primarily for energy production. The main active agents have been identified as ginsenosides, and they are the focus of much published research. Experimental models show that ginseng and ginsenosides have beneficial effects in supporting the adrenal glands; protecting the gastric mucosa; and supporting healthy body weight, blood hormones, and the gene expression of catecholamine-synthesizing enzymes. Ginsenosides also have immune-supporting and cytokinemodulating activities.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eVitamin B6, Pantothenic Acid, and Para-Aminobenzoic Acid (PABA)\u003c\/strong\u003e \u003c\/p\u003e\u003cp\u003ePantothenic acid is essential to the adrenal glands for production of the glucocorticoids. It forms pantethine in the body, which then converts to coenzyme-A—the most active metabolic enzyme in the human body needed to produce cellular energy. D-calcium pantothenate contains 91.96% pantothenic acid and is the usual supplemental form. Vitamin B6, acting as a coenzyme, has a role in the conversion of muscle glycogen to glucose, which is needed for a proper response to stressors; the synthesis of serotonin; and the support of the immune function. PABA has a role in amino acid metabolism and is needed to manufacture folic acid.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThe Thyroid Connection\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe interplay between healthy adrenal function and healthy thyroid function has long been recognized by functional medicine practitioners. In fact, cortisol acts in concert with thyroid hormone at the receptor-gene level, and a normal physiologic amount of cortisol is important for normal thyroid function.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003eTake one capsule twice daily, or as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. \u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740309074168,"sku":"b55629c2321a","price":57.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2225767099.jpg?v=1780291462"},{"product_id":"bone-support-mchc-calcium-and-magnesium","title":"Bone Support MCHC, Calcium and Magnesium","description":"\u003cp\u003eMore than 20 years of scientific research have given the name Ossopan worldwide recognition as a source of microcrystalline hydroxyapatite concentrate (MCHC). Numerous published studies support the safety, tolerability, and bone health-related effectiveness of MCHC supplementation. Studies suggest that the bioavailability of calcium from MCHC supplements may be as good as or better than the bioavailability of calcium from calcium gluconate supplements. Causenta® utilizes standardized, safe, bovine-sourced MCHC from New Zealand, a country with stringent standards. Its production features a proprietary technique that preserves the bioactive contents of bone. This process creates a naturally balanced formula because whole bone extract provides all of the nutrients found in healthy bone.\u003c\/p\u003e\u003cp\u003eUnlike other calcium supplements on the market, Ossopan consists of collagenous and non-collagenous proteins and peptides. These compounds include insulin-like growth factors I and II (IGF-I, IGF-II), transforming growth factor beta (TGF-beta), and osteocalcin, factors that stimulate alkaline phosphatase activity and support metabolism in human bone cells. Removal of the protein fraction appears to reduce the positive effects of the formula, highlighting the importance of its presence.\u003c\/p\u003e\u003cp\u003eTake two capsules with meals, twice daily, or as directed by your healthcare practitioner.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740310941944,"sku":"21333ac5fac8","price":63.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2266737516.jpg?v=1780291467"},{"product_id":"estro-performance-calcium-d-glucarate-i3c-and-dim","title":"Estro Performance Calcium D-Glucarate, I3C and DIM","description":"\u003cp\u003eThis product is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites to support estrogen balance and breast and prostate health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOverview: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eEstrogen collectively refers to the female hormones estradiol, estrone and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver to cells is to grow, divide and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance. The means in which estrogen is metabolized can result in different metabolites, each with individual biological activity. By keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites (such as I3C and DIM) work together to reduce hormone overload and maintain cellular health. Current data on I3C and DIM suggests that these phytonutrients have strong potential for supporting breast, cervical, uterine and prostate health. Together, I3C and DIM promote the creation of the favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE), metabolites which can overstimulate cells and create free radicals that cause DNA damage. The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of 2:16-alphaOHE ratio has been used to evaluate breast health. With this in mind, this product includes targeted doses of both I3C and DIM in one capsule per day dosing to make daily balancing of hormones easy and convenient. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eI3C I3C (indole-3-carbinol)\u003c\/strong\u003e is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDIM† Diindolylmethane (DIM)\u003c\/strong\u003e is a phytonutrient and plant indole also found in cruciferous vegetables with potential for enhancing proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhancing the potential for greater antioxidant activity.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCalcium D-Glucarate Calcium D-Glucarate \u003c\/strong\u003eis the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules and fat-soluble toxins. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e 2 capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740314022136,"sku":"4423472a5118","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253572076.jpg?v=1780291474"},{"product_id":"gut-defend-probiotic","title":"Gut Defend Probiotic","description":"\u003cp\u003eThe GI tract is a finely balanced environment where roughly 500 different strains of bacteria compete for space and nutrients.\u003c\/p\u003e\u003cp\u003eWhen there is a healthy balance (eubiosis), few symptoms exist. However, dysbiosis can occur when an overabundance of potentially harmful organisms prevail. The natural microflora balance can be upset by medications (such as antibiotics, oral contraceptives, etc.), excessive alcohol consumption, or poor\u003c\/p\u003e\u003cp\u003edietary intake.\u003c\/p\u003e\u003cp\u003eProbiotics have been extensively studied and are characterized as having broad GI and immune benefits, including (1) increasing the population of healthy bacteria following microflora imbalance; (2) supporting healthy bowel function; (3) increasing the production of short-chain fatty acids, which provide energy to the cells of the intestinal lining; (4) strengthening the gut-immune barrier by promoting a healthy gut mucosa; (5) aiding in the digestion of difficult-to-breakdown like lactose and casein; and (6) enhancing detoxification of harmful compounds.\u003c\/p\u003e\u003cp\u003eBecause probiotics are live organisms, there are many challenges associated with manufacturing and distributing\u003c\/p\u003e\u003cp\u003eprobiotic supplements. For a probiotic to be effective, it must be shelf-stable through the expiration date and preciselydelivered to the intestinal tract, where it can have maximum benefit. BioShield® technology is an innovative manufacturing process developed to ensure consistent and reliable results. The microorganisms in this product are protected, sealed and freeze dried away from moisture, heat, light and oxygen. This allows the bacteria to remain dormant until they are exposed to moisture in the GI tract. By utilizing advanced encapsulation\u003c\/p\u003e\u003cp\u003etechnology, the probiotic organisms are preserved and released on-target for maximum benefit.\u003c\/p\u003e\u003cp\u003eLactobacillus acidophilus (La-14)†\u003c\/p\u003e\u003cp\u003eLactobacillus acidophilus is a beneficial bacterial strain that is normally found in the intestinal tract and mouth and is commercially used in dairy products for the production of acidophilus-type yogurt. L. acidophilus ferments various carbohydrates to produce lactic acid, which increases the absorption and bioavailability of minerals. This includes calcium, copper, magnesium and manganese. The production of lactic acid also promotes health by creating an inhospitable environment for invading microbes.1 L. acidophilus has been shown to protect intestinal cells by competing for adhesion space in the gut against harmful bacteria, such as E. coli. The L. acidophilus strain in this product has been specifically chosen because of its strong adherence and survival attributes in the GI tract. It has been demonstrated in vitro to tolerate exposure to gastric acid and bile salts, and has the ability to withstand antibiotics including Ciproflaxin, Polymyxin B and Tetracycline.2\u003c\/p\u003e\u003cp\u003eLactobacillus paracasei (Lpc-37)†\u003c\/p\u003e\u003cp\u003eLactobacillus paracasei has been shown to protect against the harmful effects of bacteria such as Staphylococcus aureus (S. aureus).3 L. paracasei colonizes the intestinal tract by reinforcing defense mechanisms that support an immune response. It does this by supporting T-helper cell production and secreting secretory IgA (sIgA), an antibody critical for supporting intestinal immunity.4 L. paracasei Lpc-37 is a gastric acid-resistant strain and has been shown in vitro to withstand antibiotics such as Ciproflaxin and Vancomycin.5\u003c\/p\u003e\u003cp\u003eBifidobacterium bifidum (Bb-02)†\u003c\/p\u003e\u003cp\u003eBifidobacterium bifidum has been shown to effectively compete with harmful bacteria such as E. coli, S. aureus and\u003c\/p\u003e\u003cp\u003eCamplylobacter jejuni, which suggests B. bifidum’s lactic acid and acetic acid production provides an antagonistic action against pathogens to help maintain microflora balance.6\u003c\/p\u003e\u003cp\u003eBifidobacterium lactis (BI-04)†\u003c\/p\u003e\u003cp\u003eBifidobacterium lactis is predominantly found in the colon. A double-blind, randomized placebo-controlled trial on subjects receiving B. lactis or placebo for eight weeks found that B. lactis supported a balanced immune response in individuals hypersensitive to environmental allergens.7 Studies examining immune development and dietary supplementation with B. lactis have shown that it supports GI health by reducing\u003c\/p\u003e\u003cp\u003eintestinal permeability.8\u003c\/p\u003e\u003cp\u003eLactobacillus plantarum (Lp-115)†\u003c\/p\u003e\u003cp\u003eLactobacillus plantarum is a beneficial bacteria commonly found in fermented foods including sauerkraut, pickles,\u003c\/p\u003e\u003cp\u003ebrined olives and sourdough. L. plantarum has been found to compete against strains of Clostridium difficile and Clostridium perfringens, due to the production of bacteriocins (lethal proteins) that inhibit bacterial growth.9 Studies have also demonstrated that L. plantarum helps boost the immune response by stimulating Th1-mediated immunity.10\u003c\/p\u003e\u003cp\u003eLactobacillus rhamnosus (Lr-32)†\u003c\/p\u003e\u003cp\u003eLactobacillus rhamnosus has been proven to have remarkable survivability in the acid and bile environments in the GI tract. L. rhamnosus is particularly useful because of its ability to adhere to cells, enhance microflora balance, and inhibit pathogen adherence. L. rhamnosus was also found to positively affect inflammatory and immune gene signaling of over 1,700 genes when administered in high doses.11\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCaution \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eIf you are pregnant or nursing, consult your physician\u003c\/p\u003e\u003cp\u003ebefore taking this product.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740315234552,"sku":"6","price":102.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/853435359.jpg?v=1780291479"},{"product_id":"mood-pro-ii-taurine-l-theanine-gaba-and-5-htp","title":"Mood Pro II Taurine, L-Theanine, GABA and 5-HTP","description":"\u003cp\u003eNeurotransmitters are the chemical messengers that regulate mood, memory, sleep cycle and daily stress. Adequate neurotransmitter production depends on an adequate supply of amino acids, vitamins and minerals in the diet. High levels of stress, dietary deficiencies, genetics, medications and toxins all play a role in neurotransmitter depletion. The nutrients in this product support healthy levels of serotonin and GABA, the brain’s primary neurotransmitters for balancing the stress response. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eL-Theanine\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eL-theanine is an amino acid found abundantly in green tea. L-theanine has been shown to quickly improve stress perception and resilience. The stress-buffering mechanisms of L-theanine have been connected its ability to increase serotonin and dopamine production in the brain. L-theanine has also been shown to significantly increase alpha brain wave activity, which is critical for increasing attention as well as promoting a sense of relaxation. In a study on healthy volunteers, electroencephalograph (EEG) readings of participants were recorded following the ingestion of 50 mg of L-theanine. The researchers found a greater increase in alpha brain wave activity versus placebo. L-theanine has also been shown to have a protective effect on nerve cells overstimulated by the excitatory neurotransmitter glutamate. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePharmaGABATM\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eGamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and is a primary component of the body’s stress fighting mechanisms. GABA is also available as a dietary supplement. Most commercially available forms of GABA utilize synthetically-produced GABA, manufactured from pyrrolidinone, a compound not allowed for use in Japan. This product includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABATM. It is produced naturally by the friendly bacteria, Lactobacillus hilgardii. In contrast to synthetic GABA sources, PharmaGABATM has been shown in published research studies to promote relaxation effects in the central nervous system (CNS). In a double-blind study using healthy volunteers, EEG readings were obtained after 100 mg of PharmaGABATM was administered. PharmaGABATM produced a highly significant increase in alpha waves, as well as a significant decrease in beta waves, when compared to the control group. Alpha brain waves are associated with relaxed and effortless focus, while beta waves are associated with stress, restlessness and scattered thoughts. Therefore, an increase in alpha to beta waves is associated with improved concentration and a state of centered relaxation. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eInositol is a B vitamin that is an important component of cell membrane signaling. As part of the cellular signaling system of the CNS, inositol is crucial for the release of neurotransmitters from within the nerve cells. A deficiency of inositol can affect brain signaling, resulting in inadequate neurotransmitter release causing irritability, worry and restlessness.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTaurine\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eTaurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission due to its ability to activate GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e5-HTP\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e5-hydroxytryptophan (5-HTP) is an amino acid intermediate that is directly converted into the mood-regulating neurotransmitter serotonin. Maintaining a healthy serotonin level is important for regulating appetite and sleep cycle and for supporting a sense of calmness. As a dietary supplement, 5-HTP is produced naturally from the seeds of the African plant, Griffonia simplifolia. In contrast to L-tryptophan, 5-HTP provides efficient conversion into serotonin because it does not need prior conversion by tryptophan hydroxylase.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMicronutrients\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThis product includes essential nutrients that are required for the synthesis of serotonin and GABA neurotransmitters. This includes 5-methyltetrahydrofolate (5-MTHF), vitamin B6 (P-5-P), vitamin C, zinc and magnesium. 5-MTHF is the biologically active form of the B vitamin folic acid, which is vital for supporting proper mood regulation. 5-MTHF works together with B12 as a methyl group donor. Methyl (CH3 ) group donation is important for maintaining neurotransmitter synthesis. Magnesium is a mineral that calms the nervous system by binding to glutamate receptors, which reduces excitatory neurotransmitter activity. The combination of the minerals zinc and magnesium helps reduce glutamate to nontoxic levels, providing significant neuroprotection.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e3 capsules taken 1-3 times per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317331704,"sku":"b9fc8e4f7a76","price":114.3,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253552330.jpg?v=1780291488"},{"product_id":"muscle-aminos-bcaas","title":"Muscle Aminos - BCAAs","description":"\u003cp\u003eThe amino acid (AA) formula that comprises Muscle Aminos was meticulously developed and studied by internationally recognized researchers in the fields of muscle metabolism and aging and longevity. Seventeen years of research have resulted in this particular blend of the nine essential amino acids (EAAs)— including the branched-chain amino acids leucine, isoleucine, and valine—plus arginine, proportioned in the most optimal ratios for muscle anabolism. Muscle Aminos is designed for both young and elderly individuals who are seeking to stimulate muscle protein synthesis, hasten muscle recovery, and promote muscle strength and function.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eQuality Not Quantity \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eAmino acids are potent stimulators of muscle protein synthesis in both the young and the elderly. Of the AAs, data indicate that EAAs are primarily responsible for this biological process. Moreover, studies demonstrate that there is no additional benefit to muscle protein synthesis from adding nonessential AAs to an EAA supplement. For instance, the addition of 22 g of non-essential AAs to 18 g of EAAs produced no additional benefit to net muscle balance when compared to the provision of 18 g of EAAs alone. Likewise, a 15 g EAA supplement—with the nine EAAs in similar ratios to Muscle Aminos—had twice the impact on muscle protein synthesis than that of an equal amount (15 g) of a high-quality protein.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhy Include Arginine?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e In healthy young adults, sufficient arginine can be synthesized to meet normal demands. However, during rapid growth or in response to stress, there are heightened needs for arginine that may not be fully met. Furthermore, there is evidence that arginine has a unique stimulatory effect on muscle protein synthesis. While all mechanisms have not been fully elucidated and are likely multifactorial, it is known that arginine converts to nitric oxide, which relaxes blood vessels and improves blood flow to muscles. Last, arginine availability influences its own catabolism and that of other amino acids by controlling ureagenesis. A critical finding that solidified the need to add arginine to the EAA formulation was that without it, plasma arginine decreases; therefore, the rate of protein synthesis is potentially reduced.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eEssential Amino Acids and Exercise \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe effectiveness of EAA intake is amplified by ingestion before exercise because of the increased delivery of amino acids to the muscles. In fact, results from acute studies have shown that exercise and EAA intake have additive effects on muscle protein synthesis. Furthermore, branchedchain AAs (BCAAs), have been demonstrated to hasten post-exercise muscle recovery. Data show that BCAA (e.g., leucine) supplementation before and after exercise helps decrease exercise-induced muscle damage, promotes muscle protein synthesis, and modulates exercise-related cytokine production. For example, leucine-enriched EAA supplementation (total EAA was 10 g of which 1.85 g were leucine) prolonged the anabolic response and the sensitivity of skeletal muscle to AAs. Børsheim et al propose that over time, exercise will increase the beneficial effects of EAA supplementation on lean body mass and strength and improve functional parameters of muscles.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMuscle Loss with Aging \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eBeginning in the fourth decade of life, there is a natural and gradual decline in muscle mass (catabolism), strength, and function as a result of the innate metabolic changes and the more sedentary lifestyle that accompany aging. Studies using EAA supplementation at doses of 6.7 to 45 g\/d in advanced age, bed rest, and recovery from surgery have demonstrated important benefits. These benefits include stimulation of muscle protein synthesis, enhancements in muscle strength, and improvements in functional parameters of the studied muscle(s).\u003c\/p\u003e\u003cp\u003eIn the Elderly Protein supplements are often used to help ward off muscle-related losses in the elderly. According to Ferrando et al, “Increasing protein intake to 1.4 g\/kg\/d in the elderly with EAA supplementation indicates the potential for preserving muscle function.” Because non-essential AAs are not as effective as EAAs for muscle anabolism, supplements containing significant calories in the form of non-essential AAs may be inadequate to maximize anabolic efficiency in the elderly.[9] Furthermore, the elderly tend to use protein supplements as calorie substitutes and reduce their food intake. In these cases, it becomes critical that the AA supplement be low calorie, so as not to influence satiety, and highly efficient to confer maximum benefits to skeletal muscle. A high proportion of leucine is another factor that is required for optimal stimulation of muscle protein synthesis in the elderly. Additionally, there is evidence that the presence of carbohydrates in a nutritional supplement for the elderly is not beneficial and may actually impair muscle anabolism. Muscle Aminos is a highly efficient blend of EAAs plus arginine that provides zero carbohydrates.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eDissolve one scoop (7 g) into 8-12 oz of room-temperature water and consume once per day between meals, or use as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317397240,"sku":"cc8a9b99e0e2","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2264111395.jpg?v=1780291489"},{"product_id":"nac-n-acetyl-l-cysteine","title":"NAC (N-Acetyl-L-Cysteine)","description":"\u003cp\u003eN-Acetyl-L-Cysteine (NAC) is one of the few antioxidants found to raise glutathione levels. Glutathione is an important antioxidant used in many different metabolic processes within the body. Maintaining adequate levels is important to maintaining the health of the respiratory, hepatic and immune systems. It is also important in supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation. Glutathione is not well absorbed by the body when taken orally, so it can be difficult to sustain adequate glutathione levels. NAC has been shown to significantly increase glutathione levels. NAC is also capable of reducing the viscosity of mucous and is also used to support respiratory and pulmonary health. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDetox Support and Antioxidant Protection\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThough studies have shown the absorption of oral glutathione to be limited, supplementation with NAC has been shown to significantly increase circulating levels of glutathione in the body. Increasing glutathione levels in turn increases the production of specialized antioxidant enzymes such as glutathione peroxidase, glutathione reductase and detoxification enzymes such as glutathione S-transferases. Through the activity of these enzymes, NAC protects the body from oxidative damage, increases phase II detoxification, and enhances the normal breakdown of toxins and other metabolic byproducts of the body. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRespiratory Function\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eStudies show NAC supports normal mucous production and may positively support pulmonary and respiratory function, especially when consumed over a prolonged period. A clinical trial of 100 smokers found NAC significantly improved measures of pulmonary health, and high-dose NAC taken over a one year period resulted in significantly improved small airway clarity and decreased frequency of respiratory challenges. A systematic review found NAC to be effective in supporting children’s pulmonary health as well. NAC was also shown to support pulmonary health after inhalation of mustard gas.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eNeuropsychiatry Health\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMore recently, research has pointed to the role of NAC in targeting a diverse array of factors related to the neuropsychiatric health. NAC has been shown to protect neurons from oxidative damage, and to improve neurotransmitter production, mitochondrial function and inflammatory balance. Studies have also highlighted the role of NAC in modulating oxidative stress as its mechanism of action in neuropsychiatric health. In one 12-week, double-blind, randomized, placebo-controlled study of NAC in children with developmental delay, NAC resulted in significant improvements in irritability scores.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1 or more capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317430008,"sku":"4c27038561bc","price":55.2,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253596121.jpg?v=1780291490"},{"product_id":"optimum-b-folate-b12-and-biotin","title":"Optimum B's Folate, B12 and Biotin","description":"\u003cp\u003eA wide and complex variety of B vitamins is essential for the body to convert food into cellular energy. These water-soluble groups of vitamins are first absorbed in the small intestine and then travel to the liver where they are biotransformed into their active coenzyme forms. One of the key roles of B vitamins is to serve as prime coenzymes for the Kreb’s cycle, the biochemical pathway responsible for maintaining energy production in the form of cellular energy. In addition, B vitamins, particularly folic acid, B6 and B12, are critical for proper methylation, a biochemical process that helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. This process is vital for supporting cardiovascular and mental health, a healthy nervous system, regulating gene expression, proper energy metabolism, as well as immune and nerve cell function. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, recycle molecules that are required for detoxification and support a healthy inflammatory response. Proper methylation can be inhibited by nutrient deficiencies including folate, B2, B6 and B12. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDeficiency\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eDeficiency in any of the B vitamins can create a breakdown of metabolic processes that protect health. Many medications deplete certain B-vitamins including acetaminophen, aspirin, ibuprofen, oral contraceptives and SSRIs, along with stress and poor diet. Deficiencies of folic acid, B6 and B12 can specifically impair proper methylation, which affects many aspects of health. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFolate† \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eFolate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is found naturally in foods such as fruits and dark leafy vegetables, but can be easily destroyed by cooking or processing. Additionally, enzyme defects, malabsorption and congenital deficiency of 5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme required for the conversion of folic acid to its bioactive form 5-methyltetrahydrofolate (5-MTHF), can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF has been shown to be beneficial. 5-MTHF is required as a methyl group donor for the production of mood regulating neurotransmitters such as serotonin, the synthesis of melatonin, as well as DNA production and repair. 5-MTHF also donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the amino acid metabolite homocysteine into the amino acid methionine. Consistent recycling of homocysteine is vital to supporting cardiovascular and arterial health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThiamine (Vitamin B1)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eWhile naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential co-factor in the production of ATP in the cells’ Kreb’s cycle, and is also needed for the metabolism of fats, proteins and carbohydrates. A recent randomized double blind placebo-controlled trial found that supplementation with high-dose thiamine also supports blood sugar balance.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRiboflavin (Vitamin B2)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eRiboflavin is a precursor to flavin adenine dinucleodtide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production, intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of greater oxidative stress and disrupted energy generation. Studies have also shown that optimal riboflavin status has been found to help maintain healthy blood pressure already within normal range in patients with certain genetic predispositions.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eNiacin\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eNiacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (Nicotinamide adenine dinucleotide) and NADP (Nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells. Niacin or nicotinic acid has a long history of use in cardiovascular health, having been shown in numerous studies to support endothelial health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eVitamin B6\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eVitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for gluconeogenesis, lipid metabolism, neurotransmitter formation, immune health and hormone modulation, and is essential in methylation, for the breakdown of homocysteine. A large, prospective study found that women who consumed, on average, 4.6 mg of vitamin B6 daily had significantly better markers of cardiovascular health compared to women who consumed an average of 1.1 mg daily. In addition, vitamin B6 has been found to promote normal lymphocyte proliferation and interleukin-2 production in older people, both of which are important for optimal immune function.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eVitamin B12\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eVitamin B12, found only in organ meats, seafood and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health. In a population study of 700 women aged 65 and over, more optimal B12 levels were found to be associated with better mood balance and health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBiotin\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eSynthesized by the bacteria in the gut in addition to certain foods, biotin and its cofactors are involved in metabolism of fatty acids, amino acids and utilization of B vitamins. Biotin has also been found to support healthy blood sugar both in animal and human studies. A randomized, double-blind placebo-controlled clinical trial conducted among 70 patients, age 5-25 years old with blood sugar concerns found biotin administration to serve as an adjuvant, which improved sugar management, as well as the balance of blood fats.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePantothenic Acid\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003ePantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production. 95% of CoA is found in the mitochondria. Pantothenic acid has also been shown to have a balancing effect on blood fats in animal studies and has also been shown in the research to support wound healing.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCholine Bitartrate\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThough not technically a B vitamin, choline is often associated with B-vitamins. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development. The oxidized form of choline acts as a methyl donor in the methionine cycle. In a study of 51 men and women, subjects fed an intentionally choline-deficient diet had greater levels of lymphocyte and DNA damage. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1 or more capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740318413048,"sku":"b22bad6d2012","price":45.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2225758350.jpg?v=1780291493"},{"product_id":"sleep-performance-valerian-root-and-l-theanine","title":"Sleep Performance Valerian Root and L-Theanine","description":"\u003cp\u003e\u003cstrong\u003eDiscussion\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHuman Studies\u003c\/strong\u003e A Home Use Test (HUT) performed in 2005 among a target group of 61 men and women using SLEEP PRO II for two weeks yielded very positive results.\u003csup\u003e[1]\u003c\/sup\u003e Seventy-four percent of respondents used the product according to the directions: Take seven or more capsules during the two-week test period. Of these respondents,\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e83% said SLEEP PRO II helped them relax*\u003c\/li\u003e\n\u003cli\u003e91% said SLEEP PRO II helped reduce fatigue due to lack of sleep*\u003c\/li\u003e\n\u003cli\u003e91% said SLEEP PRO II helped ensure a good night’s sleep*\u003c\/li\u003e\n\u003cli\u003e82% said SLEEP PRO II is an essential item to have on hand*\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAn open-label, single-center, observational survey that included 295 people (ages 18-87) with sleep difficulties was performed to obtain a subjective evaluation of the tolerability and effectiveness of SLEEP PRO II.\u003csup\u003e[2]\u003c\/sup\u003e Self-reported sleep difficulties included problems falling asleep, multiple wakings, and next-day tiredness due to a lack of sleep. Patients taking at least one 365 mg capsule of SLEEP PRO II one hour before going to bed every night for at least two weeks experienced the following:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e86% considered SLEEP PRO II relaxing*\u003c\/li\u003e\n\u003cli\u003e82.8% said SLEEP PRO II assisted in a restful sleep*\u003c\/li\u003e\n\u003cli\u003e82.8% said SLEEP PRO II was effective in reducing fatigue due to lack of sleep*\u003c\/li\u003e\n\u003cli\u003eNo significant adverse events\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eSLEEP PRO II (known as SEDITOL®) is a blend of a patented extract of Magnolia officinalis bark and a proprietary extract of Ziziphus spinosa seed. These herbs have been traditionally used in Asia for qì stagnation, for mild anxiety and nervousness, and to support normal, uninterrupted sleep.*\u003csup\u003e[3-5] \u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMagnolia officinalis\u003c\/strong\u003e Magnolia bark is rich in a biphenol compound called honokiol and its isomer magnolol. In experimental animal studies, these compounds have been shown to enhance the activity of gamma-aminobutyric acid (GABA) A receptors and GABA binding, which may help the body cope with the neurologic effects emotions can have on behavior and well-being.\u003csup\u003e[4,6]\u003c\/sup\u003e Honokiol, administered by intraperitoneal injection in mice, was shown to promote NREM (non-rapid eye movement) sleep by modulating the benzodiazepine site of the GABA (A) receptor.\u003csup\u003e[5]\u003c\/sup\u003e And, in an experimental animal model of chronic mild stress, a mixture of honokiol and magnolol supported normal levels of 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in various brain regions. The combination also promoted healthy corticosterone levels and platelet adenylyl cyclase (AC) activity. Researchers suggest that these findings provide a basis for further study into the influence of magnolol and honokiol on the serotonergic system, the HPA (hypothalamic-pituitary-adrenal) axis, and the AC-cAMP pathway in relation to mood and emotional behavior.*\u003csup\u003e[7]\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eZiziphus spinosa\u003c\/strong\u003e A primary use of Z spinosa seeds in Traditional Chinese Medicine is to support calmness and help individuals with occasional sleeplessness.\u003csup\u003e[8,9]\u003c\/sup\u003e In an experimental animal model, saponins and flavonoids extracted from the seeds showed a significant relaxing effect and helped prolong sleeping time.\u003csup\u003e[8]\u003c\/sup\u003e To investigate potential mechanisms, researchers tested the influence of spinosin—a flavonoid derived from ziziphus seeds—on pentobarbital-induced sleep in mice. They concluded that it potentiated sleep via a serotonergic mechanism.*\u003csup\u003e[10] \u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eKoetter et al\u003csup\u003e[3]\u003c\/sup\u003e studied the interactions of magnolia and ziziphus extracts with selected central nervous system receptors in a series of assays. Interactions with the adenosine A1 receptor, dopamine transporter and dopamine D5 receptor (antagonist activity), serotonin receptors (5-HT1B and 5-HT6 antagonist activity), and the GABA benzodiazepine receptor were demonstrated. It is suggested that these findings provide some insight into the combined activity of these extracts.*\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eTake one to two capsules before bedtime, or as directed by your healthcare practitioner.\u003c\/p\u003e\u003cp\u003eConsult your healthcare practitioner before use. Do not use if pregnant or lactating. Do not use if tamper seal is damaged.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eReferences\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1. Seditol sleep supplement. HUT: Final report. TRG Study #82-05013. Nanuet, NY: Target Research Group; April, 2005. Study on file.\u003c\/p\u003e\u003cp\u003e2. LaValle J, Pelletier M, LaValle L, et al. A proprietary blend of Magnolia and Ziziphus extracts assists with sleep: an open-label assessment.\u003c\/p\u003e\u003cp\u003e3. Koetter U, Barrett M, Lacher S, et al. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009 Jul 30;124(3):421-25. [PMID: 19505549]\u003c\/p\u003e\u003cp\u003e4. Alexeev M, Grosenbaugh DK, Mott DD, et al. The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors. Neuropharmacology. 2012 Jun;62(8):2507-14. [PMID: 22445602]\u003c\/p\u003e\u003cp\u003e5. Qu WM, Yue XF, Sun Y, et al. Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice. Br J Pharmacol. 2012 Apr 27. doi: 10.1111\/j.1476-5381.2012.02010.x. [Epub ahead of print] [PMID: 22537192]\u003c\/p\u003e\u003cp\u003e6. Squires RF, Ai J, Witt MR, et al. Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites. Neurochem Res. 1999 Dec;24(12):1593-602. [PMID: 10591411]\u003c\/p\u003e\u003cp\u003e7. Xu Q, Yi LT, Pan Y, et al. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):715-25. [PMID: 18093712]\u003c\/p\u003e\u003cp\u003e8. Jiang JG, Huang XJ, Chen J, et al. Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Nat Prod Res. 2007 Apr;21(4):310-20. [PMID: 17479419]\u003c\/p\u003e\u003cp\u003e9. Peng WH, Hsieh MT, Lee YS, et al. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J Ethnopharmacol. 2000 Oct;72(3):435-41. [PMID: 10996283]\u003c\/p\u003e\u003cp\u003e10. Wang LE, Bai YJ, Shi XR, et al. Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system. Pharmacol Biochem Behav. 2008 Sep;90(3):399-403. [PMID: 18466960]\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDoes Not Contain\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eWheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically-modified organisms (GMOs) artificial colors, artificial sweeteners, or preservatives.\u003c\/p\u003e\u003ctable class=\"ecwid-description-table\"\u003e\u003ctbody\u003e\u003ctr\u003e\u003cth\u003e\u003cstrong\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/strong\u003e\u003c\/th\u003e\u003c\/tr\u003e\u003c\/tbody\u003e\u003c\/table\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740322050296,"sku":"a5d069f3dad7","price":70.2,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253596243.jpg?v=1780291507"}],"url":"https:\/\/causenta.com\/collections\/brain-health.oembed","provider":"Causenta","version":"1.0","type":"link"}