{"title":"Cardiovascular Health","description":null,"products":[{"product_id":"anti-ox-glucoraphanin-and-curcumin","title":"Anti Ox Glucoraphanin and Curcumin","description":"\u003cp\u003eThis product is a unique combination of phytonutrients designed to enhance antioxidant potential by stimulating nuclear factor-erythroid-2-related factor 2 (Nrf2), a dynamic pathway known to increase the production of the body’s most important cellular antioxidants. This unique combination of truebroc™, turmeric, pterostilbene, and resveratrol provides potent free radical scavenging potential, balancing of key inflammatory associated pathways, and induction of intracellular antioxidant production. These powerful phytochemicals are the basis of many “superfoods” and have extensive, peer-reviewed research supporting their dramatic effect on cell health and longevity.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOverview: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eNrf2 is a transcription factor that regulates the antioxidant response of the body. It is the primary cellular defense against the cytotoxic effects of oxidative stress. This key protein is found inside a cell and is inactive until it is released by an Nrf2 activator. Once activated, Nrf2 migrates into the nucleus and binds to DNA at the location of the master antioxidant regulator, the antioxidant response element (ARE). Studies suggest Nrf2 plays an important role in supporting the activation of cellular antioxidant systems, as well as inflammatory balance. A number of fruit and vegetable compounds have been shown to activate Nrf2 and ARE, and increase antioxidant potential. It is believed that these compounds have a protective effect on the body, help maintain a healthy cycle of inflammation, and induce cellular longevity.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBroccoli Seed Extract\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e Broccoli seed extract has the highest levels of glucoraphanin (a potent Nrf2 stimulator) of any broccoli product available. In fact, 230 mg of broccoli seed extract is equivalent to consuming 1 ¼ cups of fresh broccoli. Glucoraphanin is a phytochemical compound that acts as the precursor to sulforaphane, one of the leading compounds in broccoli that is responsible for many of its positive benefits. These compounds and their mechanisms have been studied extensively and supported by more than 500 scientific publications. Glucoraphanin and sulforaphane act as direct activators of Nrf2 and potent antioxidants shown to support detoxification and inflammatory balance. Studies show they work by improving hormone balance and increasing functional enzymes that support excretion of toxins from the body. Broccoli seed extract has been shown to remain active within the body for up to three days following consumption.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTurmeric Root Extract\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eTurmeric is a bright orange-colored spice used for thousands of years in cooking and medicine. Through its antioxidant mechanisms, the active ingredient in turmeric, curcumin, helps to maintain a healthy cardiovascular system, support gastrointestinal (GI) health, and provide neuroprotective activity. Curcumin has been shown to play a crucial role in maintaining proper inflammatory balance in a variety of bodily systems due to its ability to modulate Nrf2. Studies have shown curcumin supports the maintenance of balanced inflammation in endothelial cells and cardiac cells. Curcumin has also been found to provide antioxidant protection to the cardiovascular system by reducing oxidative stress and supporting a normal immune response.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePterostilbene\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eStilbenes make up a subgroup of phytochemicals that have potent antioxidant properties. Pterostilbene is a specific stilbene found in plant varieties like deerberry, rabbiteye blueberries, unripe pinot noir grapes, Botrytis vinifera-infected Chardonnay grapes and Xarello grapes. Through activation of Nrf2, in vitro studies show pterostilbene significantly enhances expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1) and glutathione reductase (GR). Some studies have shown antioxidant benefits may be improved when pterostilbene is combined with curcumin and resveratrol.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResveratrol\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eResveratrol, like pterostilbene, is a stilbene found in many plants and red wines. It is the most well-researched stilbene. Studies of resveratrol have found it to enhance the potential of antioxidant and detoxification activity through Nrf2 activation. Other studies have linked resveratrol to enhancing blood sugar balance, balancing inflammation and reducing oxidative stress.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e 2 capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740309893368,"sku":"46b70cbd270b","price":75.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253545200.jpg?v=1780291464"},{"product_id":"bergamot-max","title":"Bergamot Max","description":"\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003eBergamot Max\u003c\/strong\u003e features a highly concentrated source of polyphenolic antioxidants derived from bergamot (Citrus bergamia), a flavonoid-rich fruit originating from the Calabria region in southern Italy and traditionally used to support cardiovascular wellness. Research has suggested that Bergamot Polyphenolic Fraction Gold (BPFG®) is utilized hepatically to help maintain healthy cholesterol levels already within normal range and to support healthy blood glucose metabolism.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740310286584,"sku":"82","price":62.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2266764813.jpg?v=1780291466"},{"product_id":"boswellia-plus-salicin-and-boswellia","title":"Boswellia Plus Salicin and Boswellia","description":"\u003cp\u003eBoswellia Plus is formulated to support eicosanoid and cytokine balance and provide support for joint comfort. 5-LOXIN®, a patented Boswellia extract yielding concentrated 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is found to inhibit the 5-lipoxygenase enzyme. Salicin from white willow bark is a natural inhibitor of both the COX-2 and 5-lipoxygenase enzymes. Bioflavonoid-rich BerryVin™ provides additional support for eicosanoid balance and antioxidant activity.* \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhite Willow Bark (Salix alba)\u003c\/strong\u003e Willow bark has been used for thousands of years to help support eicosanoid and cytokine balance and to help relieve discomfort.[1-3] Willow bark is currently approved by the German Commission E and the European Scientific Cooperative on Phytotherapy (ESCOP) for these purposes. Willow bark is also recognized in the United States for its role in supporting joint comfort.[1] Willow bark contains glycosides, salicylates, flavonoids, tannins, aromatic compounds, and acids. A 2007 Cochrane review of the literature found moderate evidence that Salix alba positively affected eicosanoid metabolism and produced results that were comparable to those obtained by other commonly used compounds. Favorable results were obtained when the Salix alba in the studies was standardized to 120 mg or 240 mg salicin. Boswellia Plus provides a standardized 120 mg dose of salicin per serving.*[4] \u003c\/p\u003e\u003cp\u003eVarious randomized placebo-controlled studies suggest that willow bark produces positive effects on joint discomfort. The usual dose of salicin is 240 mg per day,[5] which is the intake recommendation for Boswellia Plus. Pharmacokinetic evaluations reveal that salicylic acid is the major metabolite of salicin, though other components of willow bark are believed to provide relief as well.[6] The mechanism of action of white willow bark appears to involve an effect on both arachidonic acid-derived eicosanoids and cytokine compounds.*[7] \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e5•Loxin®,\u003c\/strong\u003e a standardized Boswellia serrata extract enriched to 30% 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is ten times more concentrated than ordinary B serrata. Boswellia serrata is an ayurvedic herb whose principle constituents— boswellic acid and alpha-boswellic acid—may help maintain healthy leukotriene metabolism by reducing the activity of the enzyme 5-lipoxygenase.[8] 5-lipoxygenase (5-LOX) catalyzes the synthesis of unfavorable leukotrienes.* \u003c\/p\u003e\u003cp\u003eA randomized, double-blind, placebo-controlled trial assessing the efficacy, safety, and tolerability of Boswellia extract produced statistically significant and clinically relevant decreases in knee discomfort, increases in knee flexion, and increases in walking distance.[9] A randomized, double-blind, placebo-controlled study specifically designed with 5•Loxin resulted in statistically significant improvements in comfort and physical function and a significant reduction in matrix metalloproteinase (MMP) in synovial fluid.[10] MMP represents a class of enzymes that selectively hydrolyze peptide bonds and degrade structural proteins; they play a crucial role in the degradation of joint tissues. 5•Loxin shows significant inhibition against several MMPs. It helps prevent the formation of human recombinant TNF-α inducible MMPs, which further facilitates the maintenance of healthy cartilage and cell-cycle regulation.*[11,12] \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBerryVin™\u003c\/strong\u003e (40 mg) contains a blend of blueberries, strawberries, escobillo, and cranberries, along with grape and pomegranate extracts. This bioflavonoid-rich berry powder provides polyphenols, anthocyanins, ellagic acid, and an antioxidant capacity of 4000 TE\/g to fight free radicals. It may also provide substantial antioxidant support for soft tissues. Bioflavonoids are thought to act synergistically to inhibit cyclooxygenases, lipoxygenases, and phospholipases, ultimately supporting healthy eicosanoid metabolism and favorable cytokine balance.*[13,14]\u003c\/p\u003e\u003cp\u003eTake two capsules twice daily, or as directed by your healthcare practitioner.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740311269624,"sku":"2130980cdf44","price":50.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2280770258.jpg?v=1780291468"},{"product_id":"estro-performance-calcium-d-glucarate-i3c-and-dim","title":"Estro Performance Calcium D-Glucarate, I3C and DIM","description":"\u003cp\u003eThis product is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites to support estrogen balance and breast and prostate health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOverview: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eEstrogen collectively refers to the female hormones estradiol, estrone and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver to cells is to grow, divide and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance. The means in which estrogen is metabolized can result in different metabolites, each with individual biological activity. By keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites (such as I3C and DIM) work together to reduce hormone overload and maintain cellular health. Current data on I3C and DIM suggests that these phytonutrients have strong potential for supporting breast, cervical, uterine and prostate health. Together, I3C and DIM promote the creation of the favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE), metabolites which can overstimulate cells and create free radicals that cause DNA damage. The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of 2:16-alphaOHE ratio has been used to evaluate breast health. With this in mind, this product includes targeted doses of both I3C and DIM in one capsule per day dosing to make daily balancing of hormones easy and convenient. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eI3C I3C (indole-3-carbinol)\u003c\/strong\u003e is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDIM† Diindolylmethane (DIM)\u003c\/strong\u003e is a phytonutrient and plant indole also found in cruciferous vegetables with potential for enhancing proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhancing the potential for greater antioxidant activity.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCalcium D-Glucarate Calcium D-Glucarate \u003c\/strong\u003eis the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules and fat-soluble toxins. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e 2 capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740314022136,"sku":"4423472a5118","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253572076.jpg?v=1780291474"},{"product_id":"muscle-aminos-bcaas","title":"Muscle Aminos - BCAAs","description":"\u003cp\u003eThe amino acid (AA) formula that comprises Muscle Aminos was meticulously developed and studied by internationally recognized researchers in the fields of muscle metabolism and aging and longevity. Seventeen years of research have resulted in this particular blend of the nine essential amino acids (EAAs)— including the branched-chain amino acids leucine, isoleucine, and valine—plus arginine, proportioned in the most optimal ratios for muscle anabolism. Muscle Aminos is designed for both young and elderly individuals who are seeking to stimulate muscle protein synthesis, hasten muscle recovery, and promote muscle strength and function.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eQuality Not Quantity \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eAmino acids are potent stimulators of muscle protein synthesis in both the young and the elderly. Of the AAs, data indicate that EAAs are primarily responsible for this biological process. Moreover, studies demonstrate that there is no additional benefit to muscle protein synthesis from adding nonessential AAs to an EAA supplement. For instance, the addition of 22 g of non-essential AAs to 18 g of EAAs produced no additional benefit to net muscle balance when compared to the provision of 18 g of EAAs alone. Likewise, a 15 g EAA supplement—with the nine EAAs in similar ratios to Muscle Aminos—had twice the impact on muscle protein synthesis than that of an equal amount (15 g) of a high-quality protein.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhy Include Arginine?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e In healthy young adults, sufficient arginine can be synthesized to meet normal demands. However, during rapid growth or in response to stress, there are heightened needs for arginine that may not be fully met. Furthermore, there is evidence that arginine has a unique stimulatory effect on muscle protein synthesis. While all mechanisms have not been fully elucidated and are likely multifactorial, it is known that arginine converts to nitric oxide, which relaxes blood vessels and improves blood flow to muscles. Last, arginine availability influences its own catabolism and that of other amino acids by controlling ureagenesis. A critical finding that solidified the need to add arginine to the EAA formulation was that without it, plasma arginine decreases; therefore, the rate of protein synthesis is potentially reduced.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eEssential Amino Acids and Exercise \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe effectiveness of EAA intake is amplified by ingestion before exercise because of the increased delivery of amino acids to the muscles. In fact, results from acute studies have shown that exercise and EAA intake have additive effects on muscle protein synthesis. Furthermore, branchedchain AAs (BCAAs), have been demonstrated to hasten post-exercise muscle recovery. Data show that BCAA (e.g., leucine) supplementation before and after exercise helps decrease exercise-induced muscle damage, promotes muscle protein synthesis, and modulates exercise-related cytokine production. For example, leucine-enriched EAA supplementation (total EAA was 10 g of which 1.85 g were leucine) prolonged the anabolic response and the sensitivity of skeletal muscle to AAs. Børsheim et al propose that over time, exercise will increase the beneficial effects of EAA supplementation on lean body mass and strength and improve functional parameters of muscles.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMuscle Loss with Aging \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eBeginning in the fourth decade of life, there is a natural and gradual decline in muscle mass (catabolism), strength, and function as a result of the innate metabolic changes and the more sedentary lifestyle that accompany aging. Studies using EAA supplementation at doses of 6.7 to 45 g\/d in advanced age, bed rest, and recovery from surgery have demonstrated important benefits. These benefits include stimulation of muscle protein synthesis, enhancements in muscle strength, and improvements in functional parameters of the studied muscle(s).\u003c\/p\u003e\u003cp\u003eIn the Elderly Protein supplements are often used to help ward off muscle-related losses in the elderly. According to Ferrando et al, “Increasing protein intake to 1.4 g\/kg\/d in the elderly with EAA supplementation indicates the potential for preserving muscle function.” Because non-essential AAs are not as effective as EAAs for muscle anabolism, supplements containing significant calories in the form of non-essential AAs may be inadequate to maximize anabolic efficiency in the elderly.[9] Furthermore, the elderly tend to use protein supplements as calorie substitutes and reduce their food intake. In these cases, it becomes critical that the AA supplement be low calorie, so as not to influence satiety, and highly efficient to confer maximum benefits to skeletal muscle. A high proportion of leucine is another factor that is required for optimal stimulation of muscle protein synthesis in the elderly. Additionally, there is evidence that the presence of carbohydrates in a nutritional supplement for the elderly is not beneficial and may actually impair muscle anabolism. Muscle Aminos is a highly efficient blend of EAAs plus arginine that provides zero carbohydrates.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eDissolve one scoop (7 g) into 8-12 oz of room-temperature water and consume once per day between meals, or use as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317397240,"sku":"cc8a9b99e0e2","price":49.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2264111395.jpg?v=1780291489"},{"product_id":"nac-n-acetyl-l-cysteine","title":"NAC (N-Acetyl-L-Cysteine)","description":"\u003cp\u003eN-Acetyl-L-Cysteine (NAC) is one of the few antioxidants found to raise glutathione levels. Glutathione is an important antioxidant used in many different metabolic processes within the body. Maintaining adequate levels is important to maintaining the health of the respiratory, hepatic and immune systems. It is also important in supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation. Glutathione is not well absorbed by the body when taken orally, so it can be difficult to sustain adequate glutathione levels. NAC has been shown to significantly increase glutathione levels. NAC is also capable of reducing the viscosity of mucous and is also used to support respiratory and pulmonary health. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDetox Support and Antioxidant Protection\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThough studies have shown the absorption of oral glutathione to be limited, supplementation with NAC has been shown to significantly increase circulating levels of glutathione in the body. Increasing glutathione levels in turn increases the production of specialized antioxidant enzymes such as glutathione peroxidase, glutathione reductase and detoxification enzymes such as glutathione S-transferases. Through the activity of these enzymes, NAC protects the body from oxidative damage, increases phase II detoxification, and enhances the normal breakdown of toxins and other metabolic byproducts of the body. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRespiratory Function\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eStudies show NAC supports normal mucous production and may positively support pulmonary and respiratory function, especially when consumed over a prolonged period. A clinical trial of 100 smokers found NAC significantly improved measures of pulmonary health, and high-dose NAC taken over a one year period resulted in significantly improved small airway clarity and decreased frequency of respiratory challenges. A systematic review found NAC to be effective in supporting children’s pulmonary health as well. NAC was also shown to support pulmonary health after inhalation of mustard gas.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eNeuropsychiatry Health\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMore recently, research has pointed to the role of NAC in targeting a diverse array of factors related to the neuropsychiatric health. NAC has been shown to protect neurons from oxidative damage, and to improve neurotransmitter production, mitochondrial function and inflammatory balance. Studies have also highlighted the role of NAC in modulating oxidative stress as its mechanism of action in neuropsychiatric health. In one 12-week, double-blind, randomized, placebo-controlled study of NAC in children with developmental delay, NAC resulted in significant improvements in irritability scores.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1 or more capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317430008,"sku":"4c27038561bc","price":55.2,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2253596121.jpg?v=1780291490"},{"product_id":"optimum-ala-2","title":"Optimum ALA 2","description":"\u003cp\u003e\u003cstrong\u003eOptimum ALA 2\u003c\/strong\u003e is designed to help support cardiometabolic health. It delivers alpha-lipoic acid (ALA), the plant alkaloid berberine, and biotin in one convenient formula. These ingredients have been observed to support insulin activity and glucose metabolism. Research also suggests a role for berberine in supporting normal A1C levels.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740317823224,"sku":"80","price":78.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2266738802.jpg?v=1780291493"},{"product_id":"optimum-b-folate-b12-and-biotin","title":"Optimum B's Folate, B12 and Biotin","description":"\u003cp\u003eA wide and complex variety of B vitamins is essential for the body to convert food into cellular energy. These water-soluble groups of vitamins are first absorbed in the small intestine and then travel to the liver where they are biotransformed into their active coenzyme forms. One of the key roles of B vitamins is to serve as prime coenzymes for the Kreb’s cycle, the biochemical pathway responsible for maintaining energy production in the form of cellular energy. In addition, B vitamins, particularly folic acid, B6 and B12, are critical for proper methylation, a biochemical process that helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. This process is vital for supporting cardiovascular and mental health, a healthy nervous system, regulating gene expression, proper energy metabolism, as well as immune and nerve cell function. Methylation occurs billions of times every second and helps the body to repair DNA on a continual basis. However, when methylation processes in the body slow down, an increase in the breakage of DNA strands can occur. In addition to maintaining DNA repair, methylation reactions help maintain optimal neurotransmitter production, homocysteine balance for cardiovascular health, recycle molecules that are required for detoxification and support a healthy inflammatory response. Proper methylation can be inhibited by nutrient deficiencies including folate, B2, B6 and B12. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDeficiency\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eDeficiency in any of the B vitamins can create a breakdown of metabolic processes that protect health. Many medications deplete certain B-vitamins including acetaminophen, aspirin, ibuprofen, oral contraceptives and SSRIs, along with stress and poor diet. Deficiencies of folic acid, B6 and B12 can specifically impair proper methylation, which affects many aspects of health. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eFolate† \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eFolate is a water soluble member of the B complex vitamins that is critical for maintaining optimal methylation. Folate is found naturally in foods such as fruits and dark leafy vegetables, but can be easily destroyed by cooking or processing. Additionally, enzyme defects, malabsorption and congenital deficiency of 5-methylenetetrahydrofolate reductase (5-MTHFR), an enzyme required for the conversion of folic acid to its bioactive form 5-methyltetrahydrofolate (5-MTHF), can result in an impaired ability to activate folic acid. In individuals with a genetic defect of this enzyme, supplementation with 5-MTHF has been shown to be beneficial. 5-MTHF is required as a methyl group donor for the production of mood regulating neurotransmitters such as serotonin, the synthesis of melatonin, as well as DNA production and repair. 5-MTHF also donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the amino acid metabolite homocysteine into the amino acid methionine. Consistent recycling of homocysteine is vital to supporting cardiovascular and arterial health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eThiamine (Vitamin B1)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eWhile naturally abundant in whole grains, thiamine is lost in many of the over-processed grains commonly consumed today. Thiamine is an essential co-factor in the production of ATP in the cells’ Kreb’s cycle, and is also needed for the metabolism of fats, proteins and carbohydrates. A recent randomized double blind placebo-controlled trial found that supplementation with high-dose thiamine also supports blood sugar balance.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRiboflavin (Vitamin B2)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eRiboflavin is a precursor to flavin adenine dinucleodtide (FAD) and flavin mononucleotide (FMN), both of which are central to energy production, intermediary metabolism, and act as powerful antioxidants. Riboflavin-depleted cells have been found to display signs of greater oxidative stress and disrupted energy generation. Studies have also shown that optimal riboflavin status has been found to help maintain healthy blood pressure already within normal range in patients with certain genetic predispositions.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eNiacin\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eNiacin is a cofactor in the mitochondrial respiratory chain, which produces cellular energy. In the body, niacin is transformed into NAD (Nicotinamide adenine dinucleotide) and NADP (Nicotinamide adenine dinucleotide phosphate), which both play a role in oxidation reduction reactions in cells. Niacin or nicotinic acid has a long history of use in cardiovascular health, having been shown in numerous studies to support endothelial health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eVitamin B6\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eVitamin B6 is involved in over 100 enzymatic reactions in the body and is essential for gluconeogenesis, lipid metabolism, neurotransmitter formation, immune health and hormone modulation, and is essential in methylation, for the breakdown of homocysteine. A large, prospective study found that women who consumed, on average, 4.6 mg of vitamin B6 daily had significantly better markers of cardiovascular health compared to women who consumed an average of 1.1 mg daily. In addition, vitamin B6 has been found to promote normal lymphocyte proliferation and interleukin-2 production in older people, both of which are important for optimal immune function.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eVitamin B12\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eVitamin B12, found only in organ meats, seafood and egg yolks, often becomes deficient in vegan and vegetarian diets. The vitamin is essential for the metabolism of fats and carbohydrates, the synthesis of proteins, and also plays a role in regulating mitochondrial enzymes and energy metabolism, as well as neurological health. In a population study of 700 women aged 65 and over, more optimal B12 levels were found to be associated with better mood balance and health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBiotin\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eSynthesized by the bacteria in the gut in addition to certain foods, biotin and its cofactors are involved in metabolism of fatty acids, amino acids and utilization of B vitamins. Biotin has also been found to support healthy blood sugar both in animal and human studies. A randomized, double-blind placebo-controlled clinical trial conducted among 70 patients, age 5-25 years old with blood sugar concerns found biotin administration to serve as an adjuvant, which improved sugar management, as well as the balance of blood fats.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePantothenic Acid\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003ePantothenic acid and its biologically active derivative, CoA, are essential to the synthesis of fatty acids, membrane phospholipids, amino acids, steroid hormones, and energy production. 95% of CoA is found in the mitochondria. Pantothenic acid has also been shown to have a balancing effect on blood fats in animal studies and has also been shown in the research to support wound healing.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCholine Bitartrate\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThough not technically a B vitamin, choline is often associated with B-vitamins. It is important in the construction of cell membranes and plasma lipoproteins, plays a role in cell signaling and in the synthesis of acetylcholine (a neurotransmitter), and is vital for brain development. The oxidized form of choline acts as a methyl donor in the methionine cycle. In a study of 51 men and women, subjects fed an intentionally choline-deficient diet had greater levels of lymphocyte and DNA damage. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e1 or more capsules per day or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740318413048,"sku":"b22bad6d2012","price":45.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2225758350.jpg?v=1780291493"},{"product_id":"optimum-binder","title":"Optimum Binder","description":"\u003cp\u003eBinders have been used for centuries as a remedy for toxin exposure. For many practitioners today, binders play an important role in many detoxification protocols and have avital role in protecting the gut lining. While dietary fiber is a cornerstone in daily detoxification, selective binders like Optimum Binder are more targeted and are used to bind and remove specific toxins from the GI tract for a thorough detoxification protocol. Optimum Binder supports elimination to reduce hepatic reabsorption and help relieve toxic load. Also, for individuals with highly reactive immune systems, Optimum Binder works to limit the effects of die-off reactions and sweep toxins away from the gut lining before they can cause a severe reaction or immune response. \u003c\/p\u003e\u003cp\u003eThe mineral content in Optimum Binder comes from the purest sources across several geographic areas, from rich mineral deposits in eastern Europe to the vast mountains of central Asia. All ingredients in Optimum Binder have been thoroughly tested under strict quality protocols to ensure purity and potency.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSuggested Use:\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e2 capsules between meals or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740318773496,"sku":"89","price":51.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/3523762362.png?v=1780291495"},{"product_id":"optimum-protein-vegan-protein","title":"Optimum Protein Vegan Protein","description":"\u003cp\u003e\u003cstrong\u003eOptimum Protein\u003c\/strong\u003e is now sweetened with a natural, high-potency sweetener extracted from monk fruit. This generally recognized as safe (GRAS) monk-fruit extract offers a high-quality sweetness and flavor without the bitter aftertaste associated with some natural sweeteners. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProtein Metabolism\u003c\/strong\u003e Vegan Protein Blend is Causenta®’s proprietary blend of pea protein isolate and rice protein concentrate, L-glutamine, glycine, and taurine. Generation of glutathione and sulfation cofactors—vital for phase II conjugation—requires an array of amino acids. The combination of pea protein and rice protein, containing a complement of amino acids, achieves an amino acid score of 100%. Glutamine, a conditionally essential and versatile amino acid with two nitrogen moieties, is crucial to nitrogen metabolism and helps maintain healthy liver tissue and function.[1,2] The amino acid glycine is needed for bile synthesis, phase II detoxification, and glutathione production. Taurine, a derivative of the sulfur-containing amino acid cysteine, is also important for synthesis of bile salts and helps stabilize cell membranes.* \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eGastrointestinal Support \u003c\/strong\u003eGinger root, included to support healthy digestion such as the release of bile from the gallbladder, acts at several sites to moderate PGE(2) production and support the normal response to inflammation.[3] Fiber (from inulin and flaxseeds) supports production of short-chain fatty acids as well as a healthy intestinal flora. MeadowPure™, an organic flaxseed complex, possesses excellent oxidative stability, supports antioxidant activity, and provides lignins, soluble fiber, and omega-3 and omega-6 essential fatty acids.[4] Glutamine plays a key role in healthy intestinal cell proliferation and gut barrier integrity, immune function, and normal tissue healing.*[1,2] \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDetoxification Support\u003c\/strong\u003e Ellagic acid (from pomegranate extract) prevents over-induction of CYP1A enzymes, works at the gene level to induce synthesis of glutathione-S-transferases and other phase II activities, binds directly to toxins, and protects DNA and hepatocytes.[5,6] Watercress is a rich source of beta-phenylethyl isothiocyanate (PEITC)—a versatile compound found to inhibit phase I enzymes and induce the phase II enzymes associated with biotransformation and excretion of toxins. Watercress has been found to contain even stronger phase II inducers known as 7-methylsulfinyheptyl and 8-methylsulfinyloctyl isothiocyanates as well.[7,8] Green tea catechins not only support antioxidant activity but also appear to act as modulators of phase I and phase II detoxification.[9] Choline is present to support lipid metabolism in the liver and can be converted to betaine, a methyl donor.*[10] The active, bioavailable form of B vitamins (pyridoxal-5’-phosphate (B6), 5-methyltetrahydrofolate (folate), methylcobalamin (B12)) and glycine all support amino acid conjugation and are vital for the detoxification of xenobiotics and xenoestrogens. 5-methyltetrahydrofolate (5-MTHF), methylcobalamin, betaine, and methylsulfonylmethane (MSM) are present to support methylation and detoxification. 5-MTHF supports healthy folate nutrition, especially in individuals with variations in folate metabolism. In Optimum Protein, 5-MTHF is provided as Quatrefolic® for enhanced stability, solubility, and bioavailability.*[11] Preventium®, a patented form of potassium hydrogen d-glucarate, supports glucuronidation. Sulfation is supported by MSM and sodium sulfate. Acetylation is supported by d-calcium pantothenate, pyridoxal-5’-phosphate, and magnesium. Several minerals in Optimum Protein are provided as Albion® mineral chelates and TRAACS® mineral amino acid chelates for enhanced gastrointestinal absorption and bioavailability.*[12] \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAntioxidant Support and Cytokine Balance\u003c\/strong\u003e Bioflavonoids, quercetin, rutin, and curcumin support antioxidant activity, counter free radicals, and support healthy eicosanoid and cytokine metabolism.[13,14] Curcumin has a long history of use for its support of a normal, healthy response to inflammation.[15] N-acetylcysteine (NAC) stimulates glutathione synthesis, enhances glutathione-S-transferase activity, and promotes detoxification.[16] Selenium glycinate provides support for glutathione metabolism and antioxidant protection.*\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections: \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eBlend, shake, or briskly stir 2 level scoops (54 g) into 10-12 ounces chilled, pure water (or mix amount for desired thickness) and consume once daily, or use as directed by your healthcare practitioner. Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740319232248,"sku":"62f5ff640fe9","price":99.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2264111365.jpg?v=1780291500"},{"product_id":"performance-plus-packs-multivitamin-and-mineral-blend","title":"Performance Plus Packs Multivitamin and Mineral Blend","description":"\u003cp\u003eIt is well-established that good nutrition promotes health, while nutritional deficiencies can lead to many chronic diseases. Yet, many people underestimate the importance of achieving proper levels of micronutrients each day. For the human body to complete vital daily tasks, it must be given a wide and complex variety of key micronutrients. Micronutrients play a role in strengthening immune function and converting food into energy. They detoxify chemicals and medications, and manufacture neurotransmitters, hormones and other key signaling molecules in the body. Micronutrients also maintain tissue repair and cell regeneration. Becoming deficient in any one of these essential vitamins or minerals can create a breakdown metabolic processes that safeguard health. \u003c\/p\u003e\u003cp\u003eComprehensive studies conducted by the United States Department of Agriculture have revealed the average American diet lacks micronutrients. Nutritional deficiencies may be caused by poor nutrient levels in the soil, food transport and storage methods, and food processing techniques. In addition, deficiencies can also be caused by highly processed and refined foods, food additives, medications, alcohol consumption, smoking, heavy metal exposure and high stress levels. Whatever the reason, nutrient deficiencies exist in a substantial portion of the U.S. population and, for select nutrients, more than 80% of Americans consume less than the recommended daily allowance (RDA). Although recommended nutrient intakes (e.g., %DV, DRIs, EARs, RDAs) have been established as minimum guidelines for healthy individuals, these guidelines were not designed to address the micronutrient needs of all individuals, especially those with chronic health concerns. While these guidelines can help prevent a severe nutrient deficiency, standards such as the RDA are not a reflection of optimal daily intake. For these reasons, a daily multivitamin is a prudent choice for most individuals. This product is a superior multivitamin designed to support the ideal daily intake of vitamins and minerals by providing a high-quality source of nutrients in the most bioavailable form.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBioavailability\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe importance of bioavailability is obvious. If consuming a multivitamin has little effect on improving the body’s nutrient balance, there is no reason to ingest it. Inferior multivitamin supplements often contain synthetic vitamin E in a dl-tocopherol form. This product contains natural d-alpha tocopherol, as well as mixed tocopherols, to enhance vitamin E availability and its free radical scavenging potential.3 Another sign of an inferior multivitamin is the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide. These mineral forms have slow and limited absorption relying on adequate stomach acid to promote passive diffusion into the body. What’s more, because they remain in the intestines longer, these forms can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). This product provides a full spectrum of highly-absorbed, Albion® mineral chelates. Albion® is the world leader in manufacturing highly bioavailable mineral chelates, a specialized form of minerals bound to amino acids. This patented process creates natural mineral compounds which use active absorption mechanisms in the gastrointestinal tract to significantly enhance mineral absorption. Albion’s® mineral chelates have extensive clinical research proving their superior bioavailability, biologic activity, stability and tolerance.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eMetabolism \u0026amp; Energy Production\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eConverting food into cellular energy is a nutrient-intensive process. This product provides substantial levels of B vitamins, which are prime coenzymes for the Kreb’s cycle, the biochemical pathway responsible for maintaining energy production in the form of ATP (adenosine triphosphate). This product exclusively uses high-quality, USP-grade B vitamins ideal for those looking to boost their energy levels and support stressful lifestyles. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBroad Spectrum Antioxidant Support\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe body is constantly exposed to free radicals and relies heavily on its antioxidant reserve for protection. Free radicals are generated by metabolic by-products and environmental exposure such as UV rays from the sun, air pollution and radiation. This product contains a balanced spectrum of antioxidant vitamins such as vitamin C, mixed carotenoids, trace elements and nutrients that up-regulate antioxidant supporting pathways in the body. They work synergistically to regenerate each other and maintain adequate levels of protective antioxidants throughout the body. The USP is a scientific organization that sets standards for the identity, strength, quality and purity of medicines, food ingredients and dietary supplements, manufactured, distributed and consumed worldwide. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDirections \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003e6 capsules per day with food or as recommended by your health care professional.\u003c\/p\u003e","brand":"Causenta","offers":[{"title":"Default Title","offer_id":48740320116984,"sku":"13","price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0824\/3078\/7832\/files\/2225804593.jpg?v=1780291502"},{"product_id":"power-greens-greens-veggies-fruit-and-antioxidants","title":"Power Greens Greens, Veggies, Fruit and Antioxidants","description":"\u003cp\u003eCausenta®’s Power Greens is formulated to provide a convenient source of indispensable phytonutrients, antioxidants, fiber, and digestive enzymes to complement a healthy diet and lifestyle. A colorful blend of organic health-promoting “superfoods” have been incorporated into this all-natural greens and reds drink for their phytonutrient content and support of antioxidant activity. Truebroc™ from broccoli seed extract is added for long-lasting antioxidant and detoxification support. Probiotics, fiber, and digestive enzymes augment gastrointestinal health, absorption, and utilization of nutrients in this comprehensive superfood blend. Organic flavoring and natural sweeteners (stevia and Luo Han Guo) make Power Greens not only healthful but great tasting, as well.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOrganic Fiber Blend \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eOrganic gum acacia, inulin, and flaxseeds provide a total of 3 g of dietary fiber per scoop of Power Greens to support gastrointestinal function and probiotic activity as well as to assure multiple health benefits from increased dietary fiber intake.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOrganic Greens and Veggies Blend \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eOrganic carrots, green cabbage, broccoli, beets, chlorella, and spinach provide concentrated sources of folate, chlorophyll, carotenoids, and a multitude of phytonutrients that promote health and fight disease. The greens in Power Greens are naturally alkalizing. An alkaline pH is needed for optimal metabolic, enzymatic, repair, and immune functions in the body.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAntioxidant Support\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eAscorbic acid, organic astragalus root, organic ginger root, and organic lycium berry extract provide an antioxidant rich foundation to protect tissues from free-radical damage and promote cellular health. OxyPhyte® Ultra Blend (white tea leaf extract, apple fruit extract, and rosemary leaf extract) provides antioxidant support. 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Research suggests that GR and SFN provide long-lasting antioxidant and detoxification support that may improve overall health and well-being.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDigestive Support Blend \u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eProbiotic organisms L acidophilus, B longum, L casei, and L rhamnosus are present to maintain a healthy gastrointestinal microflora. A healthy microflora provides gastrointestinal and immune support and helps to moderate and eliminate pathogenic bacteria. Digestive enzymes (protease, amylase, bromelain, cellulase, lactase, papain, and lipase) in Power Greens assist in the breakdown of carbohydrates, fats, proteins, and lactose to enhance nutrient digestion and availability. Power Greens can be consumed by itself or as an accompaniment to any smoothie or protein drink. 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