Five Ways to Reduce Xenobiotic Exposure

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Xenobiotics are bad. They’re bad and they’re everywhere.

Xenobiotics include environmental toxins, pollutants, antibiotics, chemicals in plastics, heavy metals, synthetic estrogens, and herbicides and pesticides. When xenobiotics get into your body – usually through contaminated food, water, and air – they can wreak serious havoc, and exposure, especially early exposure, can lead to endocrine disorders, liver toxicity, a suppressed immune system, infertility, obesity, cancer, and, in large enough quantities, death.

Like I said, xenobiotics, not good.

While you can’t avoid eating, drinking water, or breathing – at least not for very long – there are some simple ways to reduce xenobiotic exposure and avoid their damaging health effects.

Five Ways to Reduce Xenobiotic Exposure

1. Just say “No!” to plastic

While ditching plastic may seem like a tall task, it’s actually quite simple. If you’re storing hot food or preparing food that needs to be reheated, use glassware. For water or other beverages you can use glass, stainless steel (like a Klean Kanteen or Hydro Flask), or a number 2 plastic container. For hot beverages like tea or coffee, stick with a traditional porcelain mug or glass.

No Plastic

As much as possible, try to avoid plastics numbered:

  • 3 – PVC; commonly found in condiment and salad dressing bottles, shower curtains, and many older baby toys
  • 6 – used in styrofoam coffee cups, take-out containers, and ubiquitous red party cups
  • 7 – unless it specifically states “BPA-free”

Another source of BPA is the lining of canned food and soda/beer cans. Say “No!” to those, too.

Xenobiotics avoided: Bisphenol A (BPA), phthlates

2. Wash your produce

Before you eat any fruits or vegetables, make sure you wash them as they’re most likely contaminated with pesticides, herbicides, and pathogenic microorganisms. Rinsing under plain warm water for 20-30 seconds is enough to remove most contaminants. You should wash fruits and vegetables that have a peel or rind, too, because bacteria can contaminate the edible portion when you cut into them.

Washing fruits and vegetables can reduce xenobiotic exposure and so can eating them. Cruciferous veggies like broccoli, cauliflower, and cabbage contain indole-3-carbinol (I3C) and diindolylmethane (DIM) that convert xenoestrogens into less harmful compounds; berries, pomegranates, and apples are rich sources of antioxidants; and garlic, tomatoes, olives, and ginger all assist with detoxification and the elimination of xenobiotics from the body.

Xenobiotics avoided: Pesticides and herbicides

3. Be VOC free

Sick building syndrome is a condition that occurs when someone moves into a new or recently renovated home or office and they get sick. A major source of that sickness is volatile organic compounds (VOCs) emitted from new paint, new furnishings, new carpeting, and new office equipment.

If you’re building a new home or renovating your current one, or even if you’re just adding new paint or carpet, be sure to choose VOC-free or low-VOC products. When cleaning your house, new or old, be sure to choose low-VOC cleaners, and to help improve indoor air quality and keep VOC levels low make sure there is adequate air flow and ventilation.

Another significant source of VOCs is dry cleaners. If you have your clothes dry cleaned, find one that doesn’t use chemicals like perchloroethylene.

Xenobiotics avoided: Solvents, chlorofluorocarbons (CFCs), benzene, perchloroethylene, formeldahyde

4. Filters are your friend

Whether it’s through direct dumping into lakes and rivers or through air pollution falling with the rain, xenobiotics tend to find their way into our water supply. We’ve written before about all the nasty stuff in tap water and the importance of at least some type of water filtration system for your home; you can add xenobiotics to the list of reasons to filter your water.

Air purifiers are a great way to remove airborne pollutants as well as allergens, dust, and mold from the air. This is especially beneficial in modern homes and offices where there is little to no ventilation due to energy saving efforts. You can find filters that are HEPA-certified that can also remove some of the VOCs in your air.

Plants are another good way to keep your air clean (and fix your feng shui). In terms of effectiveness and ease of maintenance, these are the best plants to buy:

1. Areca palm (Chrysalidocarpus lutescens)
2. Lady palm (Rhapis excels)
3. Bamboo palm (Chamaedorea erumpens)
4. Rubber plant (Ficus elastica)
5. Dracaena (Dracaena decremensis “Janet Craig”)
6. English ivy (Hedera helix)
7. Dwarf date palm (Phoenix roebelenii)
8. Ficus (Ficus macleilandii “Alii”)
9. Boston fern (Nephrolepis exaltata “Bostoniensis”)
10. Peace lily (Spathiphyllum walisii)

Xenobiotics avoided: Heavy metals, antibiotics, synthetic estrogens, VOCs, PCBs…pretty much all of them

5. Use Xenobiotic-Reducing Foods and Supplements

A healthy diet including an adequate intake of protein, essential fats, complex carbohydrates, and fiber can help reduce the harmful effects of xenobiotics. As was mentioned above, fruits and vegetables that can reduce and eliminate xenobiotics include:

  • Cruciferous vegetables – broccoli, cauliflower, cabbage, etc.
  • Berries
  • Pomegranates
  • Apples
  • Garlic
  • Tomatoes
  • Olives and olive oil
  • Ginger

Supplemental antioxidants, vitamins, minerals, probiotics, and other nutrients can help directly diminish the effects of xenobiotics, are precursors to the body’s innate detoxifiers, and support metabolic processes that eliminate xenobiotics from your body. Below are some important supplements for reducing and eliminating xenobiotics:

  • N-acetyl cysteine (NAC) is a precursor to one of the body’s most effective antioxidants – glutathione
  • Green tea extract, quercetin, and alpha lipoic acid are powerful antioxidants that assist in xenobiotic metabolism
  • B vitamins, vitamin C, and vitamin E are cofactors in metabolic processes that eliminate xenobiotics
  • Calcium D-glucarate assists in the metabolism and removal of xenobiotics and xenoestrogens
  • I3C and DIM convert toxic xenoestrogens into less harmful forms
  • Probiotics – beneficial bacteria in your gut can protect you against xenobiotics and other toxins by converting them into less harmful compounds

HPS Estro Performance2

Xenobiotics are everywhere. Unfortunately, you can’t see them and you can’t taste them, so it’s tough to avoid them. It’s also tough to know how much is too much. While the EPA and USDA have established some “safe limits,” it’s not necessarily large amounts of isolated xenobiotics that are the problem: it’s the cumulative effect of chronic low-dose exposure to multiple sources like plastics, pesticides, VOCs, etc. It’s also a matter of when exposure occurs; from the womb until adolescence, developing children are particularly susceptible to the harmful effects of xenobiotics which may not emerge until later in life. Follow the five tips above (pregnant Moms, please consult your physician before taking any supplements) to greatly reduce your exposure to xenobiotics and greatly improve your health and the health of your family.


Amara, I.B., et al., Protective effects of vitamin E and selenium against dimethoate-induced cardiotoxicity in vivo: Biochemical and histological studies. Environ Toxicol, 2011.

Bhuvaneswari, V., S.K. Abraham, and S. Nagini, Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis. Nutrition, 2005. 21(6): p. 726-31.

Claudio, L., Planting healthier indoor air. Environ Health Perspect, 2011. 119(10): p. A426-7.

Crinnion, W.J., Environmental medicine, part 2 – health effects of and protection from ubiquitous airborne solvent exposure. Altern Med Rev, 2000. 5(2): p. 133-43.

Dell’Amore, C. Cocaine, Spices, Hormones Found in Drinking Water. National Geographic News. Retrieved from:

FDA. Raw Produce: Selecting and Serving it Safely. Retrieved from:

Krizkova, J., et al., The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine. Interdiscip Toxicol, 2009. 2(3): p. 201-4.

Lii, C.K., et al., Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation. J Nutr, 2010. 140(5): p. 885-92.

Liu, T.T., et al., Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats. World J Gastroenterol, 2003. 9(12): p. 2742-4.

Mateos, R., et al., Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells. J Agric Food Chem, 2013. 61(13): p. 3264-9.

Minnesota Department of Health (MDH). Volatile Organic Compounds in Your Home. Retrieved from:

Nayak, S. and R.B. Sashidhar, Metabolic intervention of aflatoxin B1 toxicity by curcumin. J Ethnopharmacol, 2010. 127(3): p. 641-4.

Nirmala, K., T. Prasanna Krishna, and K. Polasa, Modulation of xenobiotic metabolism in ginger (Zingiber officinale Roscoe) fed rats. International Journal of Nutrition and Metabolism, 2010. 2(3): p. 56-62.

Resta, S.C., Effects of probiotics and commensals on intestinal epithelial physiology: implications for nutrient handling. J Physiol, 2009. 587(Pt 17): p. 4169-74.

Sidorova, Y.A., et al., Dose-dependent effect of alpha-tocopherol on activity of xenobiotic metabolizing enzymes in rat liver. Bull Exp Biol Med, 2003. 136(1): p. 38-41.

Smith, T.J. and C.S. Yang, Effect of organosulfur compounds from garlic and cruciferous vegetables on drug metabolism enzymes. Drug Metabol Drug Interact, 2000. 17(1-4): p. 23-49.

Sram, R.J., B. Binkova, and P. Rossner, Jr., Vitamin C for DNA damage prevention. Mutat Res, 2012. 733(1-2): p. 39-49.

The Endocrine Society. “Bisphenol A Exposure In Pregnant Mice Permanently Changes DNA Of Offspring.” ScienceDaily, 12 Jun. 2009.

Tutelyan, V.A., et al., The activity of xenobiotic-metabolizing enzymes in the liver and small intestine of rats fed low and high levels of protein. Nutrition Research, 1990. 10(10): p. 1119-1129.

University of Illinois at Chicago. “Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects.” ScienceDaily, 17 Jun. 2013. Web.

Yang, E.K., et al., Dietary lipids coinduce xenobiotic metabolizing enzymes in rat liver. Biochimica et Biophysica Acta (BBA) – Lipids and Lipid Metabolism, 1993. 1168(1): p. 52-58.

Yedjou, C.G., et al., N-acetyl-cysteine protects against DNA damage associated with lead toxicity in HepG2 cells. Ethn Dis, 2010. 20(1 Suppl 1): p. S1-101-3.

Zhang, P., et al., Different activation patterns of rat xenobiotic metabolism genes by two constituents of garlic. Carcinogenesis, 2006. 27(10): p. 2090-5.

Zhu, L., et al., Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells. J Nutr Biochem, 2010. 21(11): p. 1089-98.


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